COBRE/Tropical Medicine Seminar

May 23, 12:00pm - 1:00pm
Mānoa Campus, John A. Burns School of Medicine, Kaka’ako Campus, 651 Ilalo Street, MEB Auditorium (Room 315) Add to Calendar

"Why Does the Yellow Fever Live-Attenuated 17D Vaccine Work?" by Alan Barrett, Ph.D., Director, Sealy Center for Vaccine Development, Professor, Department of Pathology and Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, Texas

The yellow fever 17D vaccine was developed in the 1930s and has been a very effective and safe vaccine with over 600 million doses distributed. Although the vaccine has been in use for nearly 80 years we still do not understand the mechanism(s) of attenuation or immunogencity. We have been using next generation sequencing to investigate 17D vaccine and evidence will be presented that attenuation is at least in part due to lack of quasispecies population on the vaccine virus.

The yellow fever 17D vaccine was developed in the 1930s and has been a very effective and safe vaccine with over 600 million doses distributed. Although the vaccine has been in use for nearly 80 years we still do not understand the mechanism(s) of attenuation or immunogencity. We have been using next generation sequencing to investigate 17D vaccine and evidence will be presented that attenuation is at least in part due to lack of quasispecies population on the vaccine virus.


Event Sponsor
Pacific Center for Emerging Infectious Diseases Research/JABSOM Tropical Med., Mānoa Campus

More Information
Cori Watanabe, (808) 692-1654, corit@hawaii.edu, Barrett seminar (PDF)

Share by email