COBRE/Tropical Medicine Seminar

October 19, 12:00pm - 1:00pm
Mānoa Campus, John A. Burns School of Medicine, Kaka’ako Campus, 651 Ilalo Street, MEB Auditorium

"Development of Precision Medicine through Integrative DNA- and RNA-seq Data Analysis" by Youping Deng, Ph.D., Professor, Department of Tropical Medicine, Medical Microbiology and Pharmacology, Director of Bioinformatics Core, Office of Biostatistics & Quantitative Health Sciences, John A. Burns School of Medicine, University of Hawaii at Manoa.

*Veliparib is a potential anti-cancer drug acting as a PARP inhibitor. It kills cancer cells by blocking a protein called PARP, thereby preventing the repair of DNA or genetic damage in cancer cells. Based on clinical trials data of over 300 breast cancer patients with mutations in the breast cancer-related genes BRCA1 and BRCA2, we found there were almost no significant outcome (such as survival) difference between veliparib and control drugs. Through integrative exome DNA-seq and RNA-seq data analysis, we have found a certain subgroup of patients with some gene somatic mutations or gene expression changes have better response to veliparib than the control drugs. Meanwhile, a novel method to detect somatic DNA mutations with super sensitivity was developed.*


Event Sponsor
Pacific Center for Emerging Infectious Diseases Research/JABSOM Tropical Medicine, Mānoa Campus

More Information
Cori Y. Watanabe, (808) 692-1654, corit@hawaii.edu, Deng seminar (PDF)

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