Focus of this course is on the integration and synthesis of of knowledge from natural and behavioral sciences, humanities and nursing in order to conduct a comprehensive history and physical examination. Diagnostic reasoning for the purpose of clinical decision-making and problem solving will be stressed. Interview techniques will address developmental, psychosocial, cultural and occupational concerns as well as symptoms. Advanced examination skills and analysis of pertinent diagnostic data will support critical thinking and selection of accurate differential diagnoses. Faculty and preceptors facilitate laboratory and clinical experiences in a variety of settings (90 clock hours).diseases of adults, older adults and children are presented. Internal and external causative factors for disease expression including genetic, autoimmune, environmental, and biochemical will be addressed and rational therapies to prevent or control illness will be offered. Analysis of the interrelated effects of genes, environment, and lifestyle on patterns of disease in populations will be an integral part of developing evidence-based care. Relevant screening and diagnostic laboratory evaluation methods will be presented.