- The Honolulu Heart Program (HHP): Perhaps the best known research study affiliated with the Department of Geriatric Medicine is the HHP, a long-term epidemiological study of cardiovascular disease in a cohort of Japanese-American men. It is currently the largest health follow-up study of a minority group in the U.S. and began in 1965. The Principal Investigator of the HHP, Dr. J. David Curb, is also a faculty member and Director of Research for the Department of Geriatric Medicine.
- The Honolulu-Asia Aging Study (HAAS): In 1991, HAAS was initiated in the HHP cohort to study age-related problems including dementia, disability, depression and movement disorders. The Principal Investigator of the HAAS, Dr. Lon White, is on the faculty of the Department of Geriatric Medicine, and several other Geriatric Medicine faculty members are Co-Principal Investigators or Co-Investigators in the Program.
- Hawaii Lifespan Study: This is a study of genetic and environmental factors associated with longevity and healthy aging in the men of the HHP/HAAS cohort. The Principal Investigator, Dr. Bradley Willcox, is a geriatrician by training. He is on the faculty of the Department of Geriatric Medicine and actively teaches and mentors trainees.
- The Women’s Health Initiative (WHI): Hawaii is one of 40 centers for the Women's Health Initiative, a multi-center study funded by the National Institutes of Health. This is a nationwide clinical trial and observational study to address the effects of hormone replacement therapy, low fat/high fiber diet and calcium and Vitamin D supplementation on the overall health of post-menopausal women. The Hawaii Center of the Women's Health Initiative is also involved in several ancillary studies. Dr. J. David Curb is the Principal Investigator of the WHI Hawaii Center, and the Associate Chair of the Department, Dr. Kamal Masaki, is the Principal Investigator of the Women's Health Initiative Memory Study Hawaii Center.