Coursework in Khmer at the University of Hawai'i (UH) is offered by the Department of Hawaiian and Indo-Pacific Languages and Literatures and includes four levels of study (see below). Courses on other aspects of Cambodia (such as history, anthropology, archeology, art, art history, historic preservation, economics, environmental studies, peace studies, business, and Asian Studies) are offered by experts on the staff of other UH departments.

Introductory and intermediate coursework in Khmer may be used to fulfill the foreign language requirement for all bachelor's degrees on the Manoa campus. Upon completing 15 credit-hours beyond the intermediate level with a 3.0 GPA in his/her coursework, the student may apply for a Certificate in Khmer.