Department of Microbiology
University of Hawaii at Manoa
Phone: (808) 956-5518
Fax: (808) 956-5339
EducationPostgraduate Researcher, University of California-Riverside
Ph.D., National University of Singapore, Singapore
M.Sc. Harbin Normal University, China
B.Sc. Harbin Normal University, China
Dengue is the most prevalent mosquito-borne viral disease in humans. The overall objective of our research is to understand the molecular mechanisms of dengue virus-host interactions in both mosquito and human cells. We mainly focus on following research directions: (i) The role of RNAi in dengue virus-infected cells. (ii) Host cellular responses to dengue virus infection. (iii) Virulence determinants of dengue virus. (iv) Molecular mechanism of dengue virus pathogenesis.
Aliyari, R. Wu, Q., Li, H.W., Wang, X.H., Li, F., Green, L.D., Han, C.S., Li, W.X., Ding, S.W. 2008. Mechanism of induction and suppression of antiviral immunity directed by virus-derived small RNAs in Drosophila. Cell Host Microbe. 4(4):387-97.Wang, X.H., Aliyari, R., Li, W.X., Li, H.W., Kim, K., Carthew, R., Atkinson, P. and Ding, S.W. (2006) RNA interference directs innate immunity against viruses in adult Drosophila. Science. 312:452-4.
Li, H.W. and Ding, S.W. (2005) Antiviral silencing in animals. FEBS Lett. 579: 5965-73.
Lu, R., Maduro, M., Li, F., Li, H.W., Broitman-Maduro, G., Li, W.X. and Ding, S.W. (2005) Animal virus replication and RNAi-mediated antiviral silencing in Caenorhabditis elegans. Nature. 436:1040-1043.
Ding, S.W., Li, H.W., Lu, R., Li, F. and Li, W.X. (2004) RNA silencing: a conserved antiviral immunity of plants and animals. Virus Res.102(1):109-15.
Li, W.X*., Li, H.W*., Lu, R*., Li, F., Dus, M., Atkinson, P., Brydon, E.W., Johnson, K.L., Garcia-Sastre, A., Ball, L.A., Palese, P. and Ding, S.W. (2004) Interferon antagonist proteins of influenza and vaccinia viruses are suppressors of RNA silencing. Proc. Natl. Acad. Sci. U S A. 101(5):1350-5. (equal contribution)
Lu, R., Li, H.W., Li, W.X. and Ding, S.W. (2004) RNA-based immunity in insects. In Microbe-vector interactions in vector-borne diseases (Society for General Microbiology Symposium no.63), pp.63-74. Edited by S.H. Gillespie, G.L. Smith and A. Osbourn. Cambridge: Cambridge University Press.
Markarian, N., Li, H.W., Ding, S.W. and Semancik, J.S. (2004) RNA silencing as related to viroid induced symptom expression. Arch Virol. 149(2): 397-406.
Li, H.W., Li, W.X. and Ding, S.W. (2002) Induction and suppression of RNA silencing by an animal virus. Science 296: 1319-1321.
Li, H.W., Lucy A.P., Guo, H.S., Li, W.X., Ji, L.H., Wong, S.M. and Ding, S.W. (1999) Strong host resistance targeted against a viral suppressor of plant gene silencing defense mechanism. EMBO J. 18: 2683-2691.