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Using Magnetic Resonance Techniques to Study the Brain and Brain Diseases |
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Measuring Brain Blood Flow |
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Selected Publications |
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Selected publications (by Linda Chang and Thomas Ernst):
Keller MA; Venkotraman TN, Thomas A, Deveikis A, Hayes J, Berman N, Walot I, Ernst T, Chang L. Cerebral Metabolites in HIV-infected Children Followed for Ten Months with 1H-MRS. Neurology 2006 Mar;66:874-879. Tomasi D, Chang L, de Castro Caparelli EC, Telang F, Ernst T. The human immunodeficiency virus reduces network capacity: Acoustic noise effect. Annals of Neurology 2006 Feb;59:419-423. Chang L, Ernst T, Speck O, Grob C. Additive Effects of HIV and Chronic Methamphetamine Use on Brain Metabolite Abnormalities. American Journal of Psychiatry 2005 Feb 162(2):1-9. Chang L, Lee P L, Yiannoutsos CT, Ernst T, Marra C, Schiffito G, Miller EN, Jarvik J, Kolson D, Simpson D, Lenkinski R, Gonzalez RG, and Navia BA, for the HIV MRS Consortium. A Multicenter In Vivo proton MRS study of HIV-associated dementia and its relationship to age. Neuroimage, 2004 Dec;23(4):1336-1347. Cloak C, Chang L, Ernst T. Increased Frontal White Matter Diffusion is Associated with Glial Metabolites and Psychomotor Slowing in HIV. Journal of Neuroimmunology 2004 Dec;157(1-2):147-152. Wang GJ, Chang L, Volkow ND, Telang F, Logan J, Ernst T, Fowler J. Decreased brain dopamine transporters in patients with HIV-associated dementia. Brain 2004 Nov;127(Pt 11):2452-8. Epub 2004 Aug 19. Chang L, Tomasi D, Yakupov R, Lozar C, Arnold S, Caparelli EC, Ernst T. Adaptation of the Attention Network in Human Immunodeficiency Virus Brain Injury. Annals of Neurology 2004 August;56:259-272. Chang L, Ernst T, St. Hillaire C, Conant K. Antiretroviral Treatment Alters the Relationship between Chemoattractant Protein and Neurometabolites in HIV. Antiviral Therapy 2004 Jun;9(3):431-40. Keller M, Venkatraman TN, Thomas A, Deveikis A, LoPresti C, Hayes J, Berman N, Walot I, Osborn Ernst T, Chang L, Effect of Aging on Brain Metabolism in Antiretroviral-Naïve HIV Patients. Acquired Immunodeficiency Syndrome (AIDS) 2004;18(1)S61-S67. Cloak C, Chang L, Ernst T, Phillips T, Huitron-Resendiz S, Sanchez-Alavez M, Hampton V, Henriksen S. Methamphetamine and AIDS: 1HMRS studies in a Feline Model of Human Disease. Journal of Neuroimmunology 2004;147:16-20. Ernst T, Chang L, Arnold S. Increased Glial Metabolites Predict Increased Working Memory Network Activation in HIV Brain Injury. Neuroimage 2003 Aug;19(4):1686-93. Chang L, Ernst T, Witt M, Ames N, Walot I, Jovicich J, Speck O, DeSilva M, Trivedi N, Miller E. Persistent Brain Abnormalities in Antiretroviral-Naïve HIV Patients Before and 3 months after HAART. Antiviral Therapy Feb, 2003;8:17-26. Ernst T, Chang L, Jovicich J, Ames N, Gaiefsky M, Arnold Sheeba. Abnormal Brain Activation on Functional MRI in Cognitively Asymptomatic HIV patients. Neurology Nov, 2002;59(9):1343-1349. Chang L, Ernst T, Witt M, Ames N, Gaiefsky M, Miller E. Relationships Among Cerebral Metabolites, Cognitive Function and Viral Loads in Antiretroviral-Naïve HIV Patients. NeuroImage 2002;17(3):1638-1648. Chang L, Speck O, Miller E, Braun A, Jovicich J, Itti L, Ernst T. Neural Correlates Of Attention And Working Memory Deficits In Patients With HIV-1. Neurology 2001; 57:1001-1007. Ernst T, Chang L, Witt M, Aronow H, Walot I, Leonido-Yee M, Singer E. Progressive Multifocal Leukoencephalopathy and HIV-Associated White Matter Lesions in AIDS: Magnetization Transfer MR Imaging. Radiology 1999;210(2):539-543. Ernst T, Chang L, Witt M, Aronow H, Cornford M, Walot I, McBride D, Goldberg M. Cerebral Toxoplasmosis and Lymphoma in AIDS: Perfusion MR Imaging Experience in 13 Patients Radiology 1998;208(3):663-339. Chang L, Ernst T, Tornatore C, Aronow H, Melchor R, Walot I, Singer E, Cornford M. Metabolite Abnormalities in Progressive Multifocal Leukoencephalopathy by Proton Magnetic Resonance Spectroscopy. Neurology 1997;48(4):836-845. Chang L, Miller BL, McBride D, Cornford M, Oropilla G, Buchthal S, Chiang F, Aronow H, Beck K, Ernst T. Brain Lesions in Patients with AIDS: H-1 MR spectroscopy. Radiology 1995; 197:525-531 Chang L, Cornford ME, Chiang FL, Ernst TM, Sun NCJ, Miller BL. Radiologic-Pathologic Correlation: Cerebral Toxoplasmosis and Lymphoma in AIDS. American Journal of Neuroradiology (AJNR) 1995;16:1653-1663.
Chang L, Yakupov R, Cloak C, Ernst T. Marijuana use is associated with a reorganized visual attention network and cerebellar hypoactivity. Brain 2006 May;129(Pt 5):1096-112. Epub 2006 Apr 3. Chang L, Cloak C, Yakupov R, and Ernst T. Combined and independent effects of chronic marijuana use and HIV on brain metabolites. Journal of NeuroImmune Pharmacology 2006 Mar;1:65-76. Chang L, Cloak C, Patterson K, Grob C, Miller EN, and Ernst T. Enlarged Striatum in Abstinent Methamphetamine Abusers: A Possible Compensatory Response. Biological Psychiatry 2005 June:57:967-974. Chang L, Smith L, LoPresti C, Yonekura ML, Kuo J, Walot I, Ernst T. Decreased Subcortical Brain Volumes And Neuropsychological Deficits In Children Exposed To Methamphetamine In Utero. Psychiatry Research: neuroimaging 132(12);15 December 2004:95-106. Wang GJ, Volkow ND, Chang L, Fowler JS, Franceschi D, Sedler M, Miller E, Robert Hitzemann R, Zhu W, Logan J, Ma Y. Incomplete Recovery of Brain Metabolism in Methamphetamine Abusers with Protracted Abstinence. American Journal of Psychiatry 2004 (Feb);161:242-248. Chang L, Ernst T, Speck O, Patel H, DeSilva M, Leonido-Yee M, Miller E. Perfusion MRI Abnormalities and Computerized Cognitive Deficits in Abstinent Methamphetamine Users. Psychiatry Research: Neuroimaging 2002 Jun 15;114(2):65-79. Volkow N, Chang L, Wang GJ, Fowler JS, Ding YS, Sedler M, Logan J, Franceschi D, Gatley J, Hitzemann R, Gifford A, Wong C, Pappas N. Low level of brain dopamine d(2) receptors in methamphetamine abusers: association with metabolism in the orbitofrontal cortex. American Journal of Psychiatry 2001 Dec;158(12):2015-21 Volkow ND, Chang L, Wang G-J, Fowler JS, Franceschi, D, Sedler M, Gatley SJ, Miller E., Hitzemann R, Ding Y-S, Logan J. Loss of dopamine transporters in methamphetamine abusers recovers with protracted abstinence. Journal of Neuroscience 2001 Dec 1;21(23):9414-8. Volkow N, Chang L, Wang GJ, Fowler JS, Franceschi D, Sedler MJ, Gatley SJ, Hitzemann R, Ding YS, Wong C, Logan J. Higher Cortical and Lower Subcortical Metabolism in Detoxified Methamphetamine Abusers. American Journal of Psychiatry 2001;158(3):383-389. Volkow N, Chang L, Wang GJ, Fowler JS, Leonido-Yee M, Franceschi D, Sedler MJ, Gatley SJ, Hitzemann R, Ding YS, Logan J, Wong C, Miller EN. Association of Dopamine Transporter Reduction with Psychomotor Impairment in Methamphetamine Abusers. American Journal of Psychiatry 2001;158:377-382. Smith L, Chang L, Yonekura ML, Osborne D, Grob C, Ernst T. Brain proton magnetic resonance spectroscopy and imaging in children exposed to methamphetamine in utero. Neurology 2001;57(2):255-260. Smith L, Chang L, Yonekura ML, Gilbride K, Kuo J, Poland RE, Walot I, Ernst T. Brain Proton Magnetic Resonance Spectroscopy And Imaging In Children Exposed To Cocaine In Utero. Pediatrics 2001;107: 227-231. Ernst T, Chang L, Oropilla G, Gustavson A, Speck O. Cerebral perfusion abnormalities in abstinent cocaine abusers: Perfusion MRI and SPECT. Psychiatry Research: Neuroimaging 2000;99:63-74. Chang L, Ernst T, Strickland T, Mehringer CM. Gender Effects on Persistent Cerebral Metabolite Changes in the Frontal Lobes of Abstinent Cocaine Users. American Journal of Psychiatry 1999;156:716-722. Chang L, Mehringer CM, Ernst T, Melchor R, Myers H, Forney D, Satz P. Neurochemical Alterations in Asymptomatic Abstinent Cocaine Users: A Proton Magnetic Resonance Spectroscopy Study. Biological Psychiatry 1997;42(12):1105-1114.
Chang SL, Cloak C, Malellari L, Chang L. The effects of repeated endotoxin exposure on rat brain metabolites as measured by ex vivo 1HMRS. Journal of Neuroimmunology 2005 Jul 1; [Epub ahead of print]; Sep;166(1-2):39-46. Ernst T, Chang L, Cooray D, Salvador C, Jovicich J, Walot I, Boone K, Chlebowski R. The Effects of Tamoxifen and Estrogen on Brain Metabolism in Elderly Women, Journal of the National Cancer Institute 2002;94(8):592-597. Speck O, Ernst T, Braun A, Koch C, Miller E, Chang L, Gender Differences in the Functional Organization of the Brain for Working Memory, Neuroreport 2000;11:2581-2585. Ernst T, Chang L, Itti L, Speck O. Correlation of Regional Cerebral Blood Flow from Perfusion MRI and SPECT in Normal Subjects. Magnetic Resonance Imaging 1999;17(3):349-354. Chang L, Ernst T, Osborn D, Seltzer W. Leonido-Yee M, Poland RE. Proton Spectroscopy in Myotonic Dystrophy: Correlation with CTG Repeats. Archives of Neurology 1998;55(3):305-311. Ernst T, Chang L, Melchor R, Mehringer M. Frontotemporal Dementia and Early Alzheimer Disease: Differentiation with Frontal Lobe H-1 MR Spectroscopy. Radiology 1997;203:829-836. Chang L, Ernst T, Poland R, Jenden D, In Vivo Proton Magnetic Resonance Spectroscopy of the Normal Aging Human Brain, Life Sciences 1996;58 (22):2049-2056. Kreis R, Arcinue E, Ernst T, Shonk T.K, Flores R, Ross B.D, Hypoxic Encephalopathy after Near-Drowning Studied by Quantitative 1H-MR Spectroscopy: Metabolic Changes and Their Prognostic Value, Journal of Clinical Investigation 1996;97:1142-1154. Chang L, Anderson T, Migneco OA, Boone K, Mehringer CM, Villanueva-Meyer J, Berman N, Mena I. Cerebral Abnormalities in Myotonic Dystrophy: Cerebral Blood Flow, MRI and Neuropsychological Tests. Archives of Neurology 1993;50:917-923.
Kim J, Zhu W, Chang L, Bentler PM, Ernst T. Unified structural equation modeling approach for the analysis of multisubject, multivariate functional MRI data. Human Brain Mapping 2006 May 22; [Epub ahead of print]. Tomasi D, Ernst T, Caparelli EC, Chang L. Common deactivation patterns during working memory and visual attention tasks: An intra-subject fMRI study at 4 Tesla. Human Brain Mapping 2006, Jan 10 [Epub ahead of print]. Tomasi D, Caparelli EC, Chang L, Ernst T. fMRI-acoustic noise alters brain activation during working memory tasks. Neuroimage 2005;Aug 15;27(2):377-86. Tomasi D, Ernst T, Arnold S, Caparelli EC, Chang L. Practice-induced changes of brain function during visual attention: a parametric fMRI study at 4 Tesla, Neuroimage Dec 2004;23(4):1414-1421. Speck O, Ernst T, Chang L, Multi Gradient Echo Acquisition Techniques for fMRI: Advantages of Bi-Exponential Modeling, Magnetic Resonance in Medicine 2001;45:1116-1121. Jovicich J, Peters R, Koch K, Braun J, Chang L, Ernst T. Brain Areas Specific for Attentional Load in a Motion Tracking Task. Journal of Cognitive Neuroscience 2001;13:1048-1058 Itti L, Ernst T, Chang L. Automatic Scan Prescription for Brain MRI. Magnetic Resonance in Medicine 2001;45:486-494. Itti L, Chang L, Ernst T, Mishkin F. Improved 3D Correction for Partial Volume Effects in Brain SPECT. Human Brain Mapping 1997;5(5):379-388. Itti L, Chang L, Mangin JF, Darcourt J, Ernst T. Robust Multimodality Registration for Brain Mapping. Human Brain Mapping 1997;5:3-17. Ernst T, Chang L. Elimination of Artifacts in Short Echo Time 1H MR Spectroscopy of the Frontal Lobe. Magnetic Resonance in Medicine 1996;36:462-468. Ernst T, Hennig J, Improved Water Suppression for Localized In Vivo 1H Spectroscopy, Journal of.Magnetic Resonance B 1995;106:181-186. Ernst T, Hennig J, Observation of a Fast Response in Functional MR, Magnetic Resonance in Medicine 1994;32:146-149. Kreis R, Ernst T, Ross B.D., Development of the Human Brain: In Vivo Quantification of Metabolite and Water Content with Proton Magnetic Resonance Spectroscopy, Magnetic Resonance in Medicine 1993;30:424-437 (1993 SMRM Young Investigator´s Award) Kreis R, Ernst T, Ross B.D, Absolute Quantitation of Water and Metabolites in the Human Brain; Part II: Metabolite Concentrations, Journal of.Magnetic Resonance B 1993;102:9-19. Ernst T, Kreis R, Ross B.D, Absolute Quantitation of Water and Metabolites in the Human Brain; Part I: Compartments and Water, Journal of.Magnetic Resonance B 1993;102:1-8. Ernst T and Hennig J, Double-Volume 1H Spectroscopy with Interleaved Acquisitions Using Tilted Gradients, Magnetic Resonance in Medicine.1991;20:27-35. |
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Home | Publications | Investigators | Postdoctoral Researchers | Students | Staff | Usage of the 3T Scanner | Volunteers | Related Links | Calendar Neuroscience and MR Research Program, Department of Medicine—JABSOM, University of Hawaii, 1356 Lusitana Street, 7th Floor, Honolulu, HI 96813 Carol Kosaki: 808-545-8968; Linda Cunningham: 808-545-8973; Fax: 808-545-8970; Email: nmr@hawaii.edu Last update: November 2008. |
