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Christie Wilcox and Angel Yanagihara

A recent study by researchers at the University of Hawaiʻi at Mānoa, published this month in the journal Toxins, may finally put to rest the ongoing debate about whether to use cold or heat to treat jellyfish stings. Their systematic and critical review provides overwhelming evidence that clinical outcomes from all kinds of jellyfish stings are improved following treatment with hot packs or hot-water immersion.

Jellyfish stings are a growing public health concern worldwide and are responsible for more deaths than shark attacks each year. Even “mild” stings can hurt for hours to days and leave lasting scars. Despite the danger posed by these gelatinous invertebrates, scientists and medical professionals still do not agree on the best way to treat and manage jellyfish stings. At the center of the contentious debate is whether it is better to treat the sting site with heat or cold.

Box jellyfish

Heat is the key

“People think ice will help because jelly stings burn and ice is cold,” said Christie Wilcox, a postdoctoral fellow at the John A. Burns School of Medicine and lead author of the paper. “And if you Google it, many sites —even those considered reputable—will tell you to put ice on a sting to dull the pain. But research to date has shown that all marine venoms are highly heat sensitive, thus hot water or hot packs should be more effective than cold packs or ice.”

Dispelling bad web advice

“Authoritative web articles are constantly bombarding the public with unvalidated and frankly bad advice for how to treat jelly stings,” said Angel Yanagihara, assistant research professor at the Pacific Biosciences Research Center and John A. Burns School of Medicine and senior author of the paper. Yanagihara has worked for the past 18 years as director of the Pacific Cnidaria Research Laboratory and has studied the pathophysiology of jellyfish stings.

“In Hawaiʻi, and around the world, we have seen that first responders and public health decision makers rely on non-evidence-based claims found on websites. It’s not too strong to point out that in some cases, ignorance can cost lives,” said Yanagihara. “We conducted this study to rigorously assemble all the published data in hopes that policy makers will revisit this issue and carefully consider the available evidence. We are also engaged in new experimental work with models looking at vinegar effects, as well as well-designed randomized clinical trials. The goal of my laboratory’s efforts is to contribute to evidence-based best clinical practices for jellyfish stings.”

Wilcox and Yanagihara conducted a systematic review to compare the use of cold or heat in jellyfish sting treatment using a common ranking system for clinical evidence. The pair combed through more than 2,000 related articles from searches of major scientific journal article databases to find every study to date that examined the effects of using temperature-based treatments for jellyfish stings. The overwhelming preponderance of evidence supported the use of hot-water immersion (about 45 degrees Celsius). This is consistent with findings in more than a dozen articles, demonstrating that venom components are inactivated at temperatures between 40 and 50 degrees Celsius.

“I was shocked that the science was so clear, given that there is so much debate over the use of hot water,” said Wilcox. Hot-water immersion is already the standard of care for other severe marine envenomations including potentially life-threatening stonefish stings, so these results help streamline the first-aid response. “It’s simple, really: if you’re stung, use hot water or hot packs rather than ice or cold packs.”

A John A. Burns School of Medicine and Pacific Biosciences Research Center news release

This Post Has 6 Comments
  1. Does this findings about heat validate that unsubstantiated claim that a liquid already body temperature, acidic or vinegary to a degree, that we already carry around internally may be used to treat man-o-war(bluebottle) stings?

  2. Aloha Robert,

    Tests (link below) do not show any benefit of urine application in box jelly stings. It does not allow the same degree of stinging cell inactivation as vinegar and it causes some cnidae to discharge. Urine is also not hot enough for long enough to be a treatment to inhibit venom already injected as hot water immersion 42-45oC for 20-40 min

  3. I’m pretty sure the “all marine venoms are highly heat sensitive” comment is incorrect.

    Heat Stable Venoms (treat with ice, and vinegar if not Box Jelly):
    Fire Coral
    Portuguese Man-o-War
    Sea Anemone

    Heat Labile Venoms (treat with hot water immersion of at least 40 degrees C):
    Lion Fish
    Scorpion Fish
    Sea Urchin
    Weever Fish

    1. At least that’s what they’re teaching at the National Board of Diving and Hyperbaric Medical Technologists. If jellyfish venom is heat labile, the board should be informed.

  4. Any method of heating works quite well : a simple hair dryer blows the right temperature 45°C i.e. around 125°F, miraculous, your blisters disappear, not too hot to burn your skin, but breaking down the venom in a few seconds and suppressing any pain, any blisters, and preventing scars in the following days. A simple hot sheet of paper works, but hot water need an accurate temperature thermometer to be sure to be below 50°C to be sure to not burn heavily your skin and to be around 45°C to break down the venom.
    I and my wife, we used successifully this method for many around 100 jelly fish stings over the last 15 years !
    Any others methods are inefficient with pain over several days and scars many years laters sometimes.

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