Pacific Center for Emerging Infectious Diseases Research
John A. Burns School of Medicine, University of Hawai'i at Manoa
Director: Dr. Richard Yanagihara

Home

About the Center

Administration

Executive Board

Advisors

Mentors

Investigators

Collaborators

Research Projects

Pilot Projects

Technical Support Core

Conferences

Research Seminar Series

Resource Links

Publications

Contact Information

PUBLICATIONS (* Denotes researchers associated with the Pacific Center for Emerging Infectious Diseases Research.)

UH Medical School Makes Virology Cover
July 23, 2007.
Chapagain M.L., Verma S., Mercier F., Yanagihara R., and Nerurkar V.R. Polyomavirus JC infects human brain microvascular endothelial cells independent of serotonin receptor 2A. Virology 2007; 364: 55-63.

Afton, M.K., Nakata, M., Ching-Lee, M., and *Effler, P.V. Food safety for first responders. Denotes researchers associated with the Pacific Center for Emerging Infectious Diseases Research. Emerging Infectious Diseases 2005; 11:508-509.

Baek, L.J., Kariwa, H., Lokugamage, K., Yoshimatsu, K., Arikawa, J., Takashima, I., Chung, S.Y., Lee, E.J., Moon, S.S., Song, K.-J., Klein, T.A., Yanagihara, R., and Song, J.-W.: Soochong virus: A genetically distinct hantavirus isolated from Apodemus peninsulae in Korea. Journal of Medical Virology 78, 290-297, 2006.

*Bennett S.N., and Adamson, M.L. Host range of eelgrass bed fish parasite Psuedodelphis oligocotti (Nematoda: Dracunculoidea). Journal of Parasitology 2004; 90(4): 678-684.

*Bith, P. The Role of Women and the Rise of HIV/AIDS in Cambodia. Siksacakr Journal 2005.

*Bith, P. AIDS in Cambodia. Lancet Infectious Diseases August 2004; 4(8):482.

Bushley AW, Cassel K, Hernandez BY, Robinett H, Goodman MT.? A tailored multi-media campaign to promote the human papillomavirus cohort study to young women.? Prev Med 2005;41:98-101.

Bushley, A.W., Ferrell, R., McDuffie, K., Terada, K.Y., Carney, M.E., Thompson, P.J., Wilkens, L.R., Tung, K.H., Ness, R.B., and *Goodman, M.T. Polymorphisms of interleukin (IL)-1alpha, IL-1beta, IL-6, IL-10, and IL-18 and the risk of ovarian cancer. Gynecologic Oncology 2004; 95-672-679.

Chapagain ML, Nguyen T, Bui T, *Verma S, and *Nerurkar VR.: Comparison of real-time PCR and hemagglutination assay for quantitation of human polyomavirus JC.: Virology Journal 2006:9; 3(1):3.

Chua, P.K., Melish, M.E., Yu, Q., Yanagihara, R., Yamamoto, K.S., and Nerurkar, V.R.: Elevated levels of matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 during the acute phase of Kawasaki disease. Clinical and Diagnostic Laboratory Immunology 10, 308-314, 2003

Chua, P.K., *Yanagihara, R., Melish, M.E., and *Nerurkar, V.R.: Expression of adhesion molecules and monocyte chemoattractant protein-1 in human coronary artery endothelial cells stimulated with tumor necrosis factor-a and salicylic acid: Pathogenetic mechanism of Kawasaki syndrome.? Cellular and Molecular Biology 49, 1157-1166, 2003.

*Effler, P.V., Pang, L., Kitsutani, P., Vorndam, V., Nakata, M., Ayers, T., Elm, J., Tom, T., Reiter, P., Rigau-Perez, J.G., Hayes, J.M., Mills, K., Napier, M., Clark, G.C., and Gubler, D.J. Dengue Fever, Hawaii, 2001-2002. Emerging Infectious Disease 2005; 11(5): 742-744.

*Erdem, G., Ford, J., Mizumoto, C., Abe, L., *Yamaga, K., Johnson, D., *Kaplan, E. Erythromycin resistant group A streptococcal isolates from Oahu, Hawaii. Journal of Clinical Microbiology 2005;43(5):2497-2499.

*Erdem, G., Abe, L., Kanenaka, R.Y., Pang, L., Mills, K., Mizumoto, C., *Yamaga, K., and *Effler, P.V. Characterization of a community cluster of group A streptococcal invasive disease in Maui, Hawaii. Pediatric Infectious Disease Journal 2004; 23: 677-679.

*Erdem, G., Ford, J., Kanenaka, R.Y., Abe, L., *Yamaga, K., and *Effler, P. Molecular epidemiologic comparison of two group A streptococcal necrotizing fasciitis community clusters in Hawaii. Clinical Infectious Diseases 2005; 40:1851-4.

*Erdem G , Hernandez X, Kyono M, Chen-Nishina C, Iwaishi LK. In-utero lead intoxication after parenteral ingestion of Mexican pottery: inadequacy of lead exposure questionnaire. Clin Pediatr 2004;43:185-7.

*Erdem G , Medina LA, Breault MA, Ford J, Yamaga K, Abe L, Easa D. Pharyngeal Prevalence and emm Types of Group A Streptococci in Students from Different Ethnic Groups in Oahu, Hawaii. Ped Inf Dis J ( in preparation)

*Erdem G, Ford J, Abe L, Yamaga K, Johnson D, Kaplan E. Erythromycin-resistant group A streptococcal isolates from Oahu, Hawaii. J Clin Microbiol 2005;43:2497-99.

Foster, J.E., *Bennett, S.N., Carrington, C.V.F., Vaughan, H., and McMillan, W.O. Phylogeography and molecular evolution of dengue 2 in the Caribbean Basin, 1981-2000. Virology 2004; 324(1): 48-59.

Friedlaender, J., Schurr, T., Gentz, F., Koki, G., Friedlaender, F., Horvat, G., Babb, P., Cerchio, S., Kaestle, F., Schanfield, M., Deka, R., Yanagihara, R., and Merriwether, D.A.: Expanding Southwest Pacific mitochondrial haplogroups P and Q. Molecular Biology and Evolution 22, 1506-1517, 2005.

Friedlaender, J., Schurr, T., Gentz, F., Koki, G., Friedlaender, F., Horvat, G., Babb, P., Cerchio, S., Kaestle, F., Schanfield, M., Deka, R., *Yanagihara, R., and Merriwether, D.A. Expanding Southwest Pacific mitochondrial haplogroups P and Q. Molecular Biology and Evolution 2005 April 6; [Epub ahead of print]

Goodman MT, *Hernandez BY, Hewitt S, Lynch CF, Cote TR, Frierson HF Jr, Moskaluk CA, Killeen JL, Cozen W, Key CR, Clegg L, Reichman M, Hankey BF, Edwards B. Tissues from population-based cancer registries: a novel approach to increasing research potential.? Hum Pathol 2005;36:812-20.

*Hernandez BY, McDuffie K, *Goodman MT, Wilkens LR, Thompson P, Zhu X, Wong W, Ning L. Comparison of physician- and self-collected genital specimens for the detection of human papillomavirus in men. J Clin Microbiol 2006;44:513-7.

*Hernandez, B.Y., Shiramizu, B. Viruses and cancer. Hawaii Medical Journal 2005; 64:106-108.

*Hernandez, B.Y., McDuffie, K., Franke, A.A., Killeen, J., *Goodman, M.T. Plasma and dietary phytoestrogens and risk of premalignant lesions of the cervix. Nutrition and Cancer 2004; 49: 109-124.

*Hernandez, B.Y., Frierson, H.F., Jr., Moskaluk, C.A., Li, Y.J., Clegg, L., Cote, T.R., McCusker, M.E., Hankey, B.F., Edwards, B.K., *Goodman, M.T. CK20 and CK7 protein expression in colorectal cancer: demonstration of the utility of a population-based tissue microarray. Human Pathology 2005; 36: 275-281.

*Hernandez BY, McDuffie K, Zhu X, Wilkens LR, Killeen J, Kessel B, Wakabayashi MT, Bertram CC, Easa D, Ning L, Boyd J, Sunoo C, Kamemoto L, *Goodman MT. Anal HPV infection in women and its relationship with cervical infection. Cancer Epidemiol Biomarkers Prev 2005;14:2550-2556.

*Hernandez B.Y., *Goodman M.T. Ethnic Disparities in Colorectal Cancer Incidence and Mortality in Hawaii. Hawaii Medical Journal 2004:63:54-56.

*Hernandez BY, McDuffie K, Franke AA, Killeen J, and *Goodman MT. Plasma and dietary phytoestrogens and risk of premalignant lesions of the cervix. Nutr Cancer 2004;49:109-24.

*Hernandez, B.Y., McDuffie, K., Kamemoto, L., *Goodman, M.T. Diet and high-grade premalignant lesions of the cervix: evidence of a protective role for folate, riboflavin, thiamin, and vitamin B12. Cancer Causes Control 2003; 14(9):859-870.

Hoffmann, P.R., Woodrow, R.J., Calimlim, P.S., Scuilli, R., *Effler, P., Miyamoto, V., *Imrie, A., *Yanagihara, R., and *Verurkar, V.R. West Nile virus surveillance: a simple method to amplify Aedes and Culex mosquito gene sequence. Journal of Medical Entomology 2004; 41(4): 731-735.

Imrie A, Zhao Z, Bennett SN, Kitsutani P, Laille M, Effler P. Introduction of two distinct strains of dengue 1 into Hawaii. Annals of Tropical Medicine and Parasitology 2006;100:327-336.

Iverson, C.J., Wang, S.A., Lee, M.V., Ohye, R.G., Trees, D.L., Knapps, J.S., *Effler, P.V., O'Connor, N.P., and Levine, W.C. Fluoroquinolone resistance among Neisseria gonorrhoeae isolates in Hawaii, 1990-2000: Role of foreign importation and increasing endemic spread. Sexually Transmitted Diseases 2004; 31:702-708.

Katz AR, Nekorchuk DM, Holck PS, Hendrickson LA, Imrie A, Effler PV. Hawaii physician and nurse bioterrorism preparedness survey. Prehospital and Disaster Medicine 2006;21:404-413.

Katz AR, Nekorchuk DM, Holck PS, Hendrickson LA, *Imrie AA, *Effler PV. Dentists’ preparedness for responding to bioerrorism: A survey of Hawaii dentists. Journal of the American Dentists Association 2006; 137:461-467.

Katz, A.R., Lee, M.V., Ohye, R.G., *Effler, P.V., Johnson, E.C., and Nishi, S.. Prevalence of chlamydial and gonorrheal infections among females in a juvenile detention facility, Honolulu, Hawaii. Journal of Community Health 2004; 29:265-9.

Katz, A.R., Effler, P.V., Ohye, R.G., and Lee, M.V.C. Assessing Age-Related Risk for Gonococcal and Chlamydial Infections Among Females in Hawaii, 2001: A comparison of Morbidity Rates With Screening Test Positivity. Ambulatory Pediatrics 2004; 4:188-191.

Lasher, L.E., Ayers, T.L., Amornkul, P.N., Nakatab, M.N., and *Effler, P.V. Contacting passengers after exposure to measles on an international flight: Implications for responding to new disease threats and bioterrorism. Public Health Report 2004; 119: 458-463.

Leung, W.H., Meng, Z.Q., *Hui, G., and Ho, W.K.K. Expression of an immunologically reactive merozoite surface protein (MSP-142) in E. coli. Biochemica Biophsica Acta 2004; 1675:62.

Lorenzo, E., Colon, M.C., Almodovar, S., Maldonado, I.M., Gonzalez, S., Costa, S.E., Hill, M.D., Mendoza, R., Sepulveda, G., *Yanagihara, R., *Nerurkar, V.R., Kumar, R., Yamamura, Y., Scott, W.A., and Kumar, A. Influence of CD4+ T cell counts on viral evolution in HIV-infected individuals undergoing suppressive HAART. Virology 2004; 330: 116-126.

Lu, Y., Aguirre, A.A., Wang, Y., Zeng, L., Loh, P.C., *Yanagihara, R. Viral susceptibility of newly established cell lines from the Hawai`ian monk seal, Monachus schauinslandi. Journal of Aquatic Diseases 57(3), 183-191, 2003.

Lu, Y.A., Wang, Y., Aguirre, A.A., Zhao, Z.S., Liu, C.Y., *Nerurkar, V.R., *Yanagihara, R. RT-PCR detection of the expression of the polymerase gene of a novel reptilian herpesvirus in tumor tissues of green turtles with fibropapilloma. Archives of Virology 148(6):1155-1163. 2003

Modugno, F., Ness, R.B., Allen, G.O., Schildkraut, J.M., Davis, F.G., and *Goodman, M.T. Oral contraceptive pill use, reproductive history, and risk of epithelial ovarian cancer in women with and without endometriosis. American Journal of Obstretrics and Gynecology 2004; 191: 733-740.

Nerurkar PV, Lee YK, Linden EH, Lim S, Pearson L, Frank J, Nerurkar VR.? Lipid lowering effects of Momordica charantia (bitter melon) on cellular lipids and apolipoproteins in HIV protease inhibitor-treated human hepatoma cells. British Journal of Pharmacology 2006; 148:1156-1164.

Nerurkar, P.V., Pearson, L., Efird, J.T., Adeli, K., Theriault, A.G., and *Nerurkar, V.R. Microsomal triglyceride transfer gene expression and ApoB secretion are inhibited by bitter melon in HepG2 cells. Journal of Nutrition 2005; 135:702-706.

Nerurkar, P.V., Pearson, L., Frank, J.E., *Yanagihara, R., and *Nerurkar, V.R.: HAART-associated lactic acidosis: In vitro effects of combination of nucleoside analogues and protease inhibitors on mitochondrial function and lactic acid production. Cellular and Molecular Biology 49, 1205-1211, 2003.

Nigro, O., Yu, Q., *Nerurkar, V.R., *Yanagihara, R., and Lu, Y.: Sequence and characterization of a novel DNA-binding protein gene of a reptilian herpesvirus associated with green turtle fibropapilloma. Archives of Virology 149, 337-347, 2003.

Okumura, M., Yoshimatsu, K., Kumperasart, S., Nakamura, I., Ogino, M., Taruishi, M., Sungdee, A., Pattamadilok, S., Ibrahim, I.N., Erlina, S., Agui, T., Yanagihara, R., and Arikawa, J.: Development of serological assays for Thottapalayam virus, an insectivore-borne hantavirus. ?Clinical and Vaccine Immunology 2007 (published on-line December 20, 2006).

Shiramizu B, Shikuma KM, Kamemoto L, Gerschenson M, *Erdem G, Pinti M, Cossarizza A, Shikuma C. Placenta and cord blood mitochondrial DNA toxicity in HIV- infected women receiving nucleoside reverse transcriptase inhibitors d uring pregnancy. JAIDS 2003;32:370-4.

Smith, C.E., Tom, T., Sasaki, J., Ayers, T., and *Effler, P.V. Dengue Risk among Visitors to Hawaii during an Outbreak. Emerging Infectious Diseases 2005; 11(5): 750-6.

Song, J.-W., Baek, L.J., Song, K.-J., Skrok, A., Markowski, J., Bratosiewicz-Wasik, J., Kordek, R., Liberski, P.P., *Yanagihara, R. Characterization of Tula virus from common voles (Microtus arvalis) in Poland: evidence for geographic-specific phylogenetic clustering. Virus Genes 2004; 29(2): 239-247.

Taniguchi, L., Darling, S., Kon, K., and *Erdem, G. Soft tissue infection caused by Kluyvera species. Pediatric Infectious Disease Journal 2005; 24:93-94.

Tonry JH, Brown CB, *Cropp CB, Co J, *Bennett S, *Nerurkar VR, Kuberski T, and *Gubler DJ. Detection of West Nile virus RNA in the urine of a patient with encephalitis. Emerging Infectious Diseases 2005;11:1294-1296.

Tung, K.-H., Wilkens, L.R., Wu, A.H., McDuffie, K., Nomura, A.M.Y., Kolonel, L.N., Terada, K., and *Goodman, M.T. Effect of anovulation factors on pre- and post-menopausal ovarian cancer risk: Revisiting the incessant ovulation hypothesis. American Journal of Epidemiology 2005; 161: 321-329.

Tung, K.-H., Wilkens, L.R., Wu, A.H., McDuffie, K., Hankin, J.H., Nomura, A.M.Y., Kolonel, L.N., *Goodman, M.T. Association of dietary vitamin A, carotenoids, and other antioxidants with the risk of ovarian cancer. Cancer Epidemiology and Biological Control 2005; 14:1-8.

Verma, S., Ziegler, K., Ananthula, P., Co, J.K.G., Frisque, R.J., Yanagihara, R., and Nerurkar, V.R.:? JC virus induces altered patterns of cellular gene expression: Interferon-inducible genes as major transcriptional targets. Virology 345, 457-467, 2006.

Zeng, L.B., Planelles, V., Sui, Z., Gartner, S., Maggirwar, S., Dewhurst, S., Ye, L.B., Nerurkar, V.R., Yanagihara, R., and Lu, Y.: Human immunodeficiency virus type 1 (HIV-1) based defective lentiviral vectors efficiently transduce human monocyte-derived macrophages and suppress replication of wild-type HIV-1. Journal of Gene Medicine 8, 18-28, 2006.

Ziegler, K., Bui T., Frisque, R.J., Grandinetti, A., *Nerurkar, V.R. A rapid in vitro polyomavirus DNA replication assay. Journal of Virological Methods 2004(122):123-127.

In press

*Erdem, G. Pediatric HIV infection. The electronic textbook of pediatrics. Yamamoto L (ed).

*Erdem, G. Sepsis. The electronic textbook of pediatrics. Yamamoto L (ed).

Shiramizu B, Hu N, and Nerurkar VR. High prevalence of human polyomavirus JC VP1 gene sequences in pediatric malignancies. Cellular and Molecular Biology 2006.

Abstracts and Presentations

Abe, L., *Erdem, G., Imai, C., Jonson, D.R., *Kaplan, E.L., and *Yamaga, K.M. Comparison between an invasive and non-invasive isolate of streptococcus pyogenes obtained from the same patient. In: Abstracts of the ASM Conference on Functional Genomics and Bioinformatics Approaches to Infectious Disease Research, Portland, Oregon, October 2004.

Abe L, Garcia AF, *Erdem G, Kaplan EL, Johnson DR, Imai CA, *Yamaga K. Temporally Related Noninvasive and Invasive Group A Streptococcus Isolates from a Single Patient. XVIth Lancefield International Symposium on Streptococci and Streptococcal Diseases, Cairns, Australia, September 2005.

Aumakhan, A., Bui, T., Tsend, N., Purevdawaa, E., Nyamkhu, D., Miller, F.D., *Yanagihara, R., and *Nerurkar, V.R. HIV subtype A in Mongolia. US-Japan Cooperative Medical Sciences Program, 8th Meeting on Emerging Infectious Diseases, December 11-13, 2003, Dhaka, Bangladesh.

Ellis N, Kurahara D, Vohra H, Blanco A, Adderson E, Veasy LG, Tam E, Yamaga K, Erdem G, Hill H, Cunningham M. Priming the immune system for heart disease: A global perspective on epitopes of human cardiac myosin and streptococcal M protein in rheumatic carditis (oral presentation). XVIth Lancefield International Symposium on Streptococci and Streptococcal Diseases, Cairns, Australia September 2005.

*Erdem, G., Ford, J., Kanenaka, R.Y., Abe, L., Mizumoto, C., Yamaga, K., and Effler, P. Characterization of group A streptococcal isolates causing severe disease in Hawaii following an outbreak of necrotizing fasciitis in Maui, Hawaii. In: Abstracts of the 44th Interscience Conference on Antimicrobial Agents and Chemotherapy, Washington DC, October 2004.

*Erdem, G., Medina, L.A., Breault, M.A., Ford, J., *Yamaga, K., Abe, L., and Easa, D.
Pharyngeal prevalence and emm types of group A streptococci in students from different ethnic groups in Oahu, Hawaii. Pediatric Academic Societies Annual Meeting, San Francisco, California, May 2004.

*Erdem, G., Ford, J., Mizumoto, C., Abe, L., *Yamaga, K., Johnson, D., and *Kaplan, E.
Macrolide/clindamycin resistant group A streptococci in Hawaii. Pediatric Academic Societies Annual Meeting, San Francisco, California, May 2004.

*Erdem G , Mizumoto C, Esaki D, *Yamaga K, Abe L, Reddy V, Johnson D, Kurahara D, Yamamoto K, Kaplan D. Comparison of emm types classically associated with acute rheumatic fever in Continental United States and emm types identified from Hawaii patients (oral presentation). Infectious Diseases Society of America Annual Meeting, San Francisco, CA, October 2005 .

*Erdem G , Ford J, Reddy V, *Yamaga K, Abe L, Johnson D, Kanenaka R, Effler P, Kaplan EL. Group A streptococcal emm types associated with clinical disease in Hawaii. XVIth Lancefield International Symposium on Streptococci and Streptococcal Diseases, Cairns, Australia, September 2005.

*Erdem G , Ford J, *Yamaga K, Abe L, Johnson D, Reddy V, Kurahara D, Yamamoto K, Mizumoto C, Esaki D, Kaplan D. Acute rheumatic fever associated emm types in Hawaii. XVIth Lancefield International Symposium on Streptococci and Streptococcal Diseases, Cairns, Australia, September 2005.

*Erdem G , Ford J, Esaki D, Mizumoto C, *Yamaga K, Abe L, Johnson D, Effler P, Kanenaka R, Kaplan EL. Identification of unusual emm sequence types among Streptococcus pyogenes clinical isolates in Hawaii. Infectious Diseases Society of America Annual Meeting, San Francisco, CA, October 2005 .

*Erdem G , Sinclair S, Medina L, Maureen C, Mizumoto C, Esaki D, *Yamaga K, Abe L, Johnson D, Kaplan E. Group A streptococcal pharyngeal prevalence among asymptomatic school-aged children in Oahu, Hawaii: a region with high incidence of acute rheumatic fever. Infectious Diseases Society of America Annual Meeting, San Francisco, CA, October 2005 .

Garcia A, Abe L, *Erdem G, *Yamaga K. Expression of streptococcal pyrogenic exotoxin B in two temporally different Streptococcus pyogenes isolates from a single Patient. 2005 JABSOM Biomedical Sciences Symposium.

*Hernandez, B. Concurrent cervical and anal HPV infection in a multiethnic cohort of women in Hawaii. Poster presentation at the International Papillomavirus Conference, Mexico City, Mexico, February 2004.

*Hui, G., and Hashimoto, C. Immunogenicity of P. falciparum MSP1: Effects of immune gene knockouts on adjuvants' efficacy. In: Abstracts of the 53rd annual meeting of the American Society of Tropical Medicine and Hygiene, Miami, Florida, November 7-11, 2004.

*Imrie, A. An outbreak of dengue-1 in Hawaii, 2001-2002. Seminar, Hawaii State Department of Health State Laboratory Division, November 2003.

Komatsu, R., Nguyen, L.T., Mai, A.H., Ly, D.P., Nguyen, H.T., *Nerurkar, V.R., *Yanagihara, R., and Brown, T. HIV infection and associated risk factors among high-risk women in southern Vietnam. In: Abstracts of the Seventeenth Meeting of the AIDS Panels, United States-Japan Cooperative Medical Science Program, Kyoto, Japan, December 8-10, 2004; also, Abstracts of the XVth Asia-Pacific Military Medicine Conference, Hanoi, Vietnam, May 8-13, 2005.

Nguyen, D.T., Son, M.S., and Hoang, T.T. Reverse regulation of Fatty Acid Degradation Relative to Fatty Acid Biosynthesis in P. aeruginosa. Poster number B-076, presented 06/06/2005 at the National Society for Microbiology, Atlanta, GA.

Pladevega, A., *Yamaga, K.M., Abe, L., and *Erdem, G. Inhibition of Streptococcus pyogenes serum opacity factor by type specific antibodies. In: Abstracts of the Annual Biomedical Research Conference for Minority Students (ABRCMS), Dallas, Texas, November 2004.

Pladevega, A., Abe, L., *Erdem, G., and *Yamaga, K. Setting the parameters to test for antibodies against common serum opacity factor producing group A streptococcal strains in Hawaii. JABSOM Biomedical Sciences Symposium.

Pladevega A, Abe L, Erdem G, Yamaga K. SOF-typing of uncommon group A streptococci strains found in Hawaii. 2005 JABSOM Biomedical Sciences Symposium.

Shiramizu B, Shikuma KM, Kamemoto L, Gerschenson M, Erdem G, Pinti M, Cossarizza A, Shikuma C. Placenta and cord blood mitochondrial DNA toxicity in HIV- infected women receiving nucleoside reverse transcriptase inhibitors d uring pregnancy. 10 th Conference on retroviruses and opportunistic infections, Boston, MA, February 2003.

Son, M.S. and Hoang, T.T. Identification of Genes Involved in Lung Surfactant Lipid Metabolism in Pseudomonas aeruginosa Using Microarrays. Poster number B-075, presented 06/06/2005 at the National Society for Microbiology, Atlanta, GA.

Tice, A., and *Nerurkar, V.R. Fatal respiratory virus infection. 2nd Infectious Diseases Conference, Queen?s Medical Center, Honolulu, Hawaii, January 31, 2004.

*Verma, S., Bui, T., Frisque, R.J., *Yanagihara, R., and *Nerurkar, V.R. Pathogenesis of progressive multifocal leukoencephalopathy (PML): Global modulation of host gene expression. 10th Conference on Retroviruses and Opportunistic Infections, San Francisco, California, February 8-12, 2004.

*Verma, S., Bui, T., Frisque, R.J., *Yanagihara, R., and *Nerurkar, V.R. Pathogenesis of progressive multifocal leukoencephalopathy: Altered patterns of cellular gene expression. 13th Joint Meeting of AIDS Panel, Japan-U.S. Cooperative Medical Science Program, Nashville, Tennessee, March 8-10, 2004.

*Verma, S., Ziegler, K., Bui, T., Frisque, R.J., *Yanagihara, R., and *Nerurkar, V.R. Altered patterns of cellular gene expression by JC virus [abstract no. W22-4] In: Abrstacts of the 23rd annual meeting of the American Society for Virology, Montreal, Canada, July 10-14, 2004, p. 119.

*Yanagihara, R. Gifts of civilization: Revisited. Keynote lecture, annual meeting of the Association of Medical School Microbiology and Immunology Chairs, Waikoloa, Hawai`i, January 21-25, 2004.

*Yanagihara, R. Gifts of civilization: A historical perspective and update on selected vector-borne and zoonotic diseases in Hawaii. Keynote lecture. Hawaii Bioscience Conference, Honolulu, January 13-14, 2005.

*Yanagihara, R. Gifts of civilization: vector-borne and zoonotic infectious diseases in Hawaii. Special Seminar, Keio Economic Society, Keio University, Tokyo, Japan, February 26, 2005.

*Yanagihara, R. Gateway consortium: A model for HIV Surveillance and Prevention. Inaugural meeting of the Center for Research and Education on Health Disparities of AIDS in the Caribbean, Guanica, Puerto Rico, January 29-30, 2004.

*Yanagihara, R. Vietnam PDVI Site. First Research Network Meeting, Pediatric Dengue Vaccine Initiative, Targeted Vaccine Safety Research, San Francisco, California, June 1-2, 2004.

*Yanagihara, R., Doetsch, P.E., Song, J.-W., and Schmaljohn, C.S. Thottapalayam virus: Partial characterization of an insectivore-borne hantavirus. Plenary lecture. Sixth International Conference on HFRS, HPS and Hantaviruses, Seoul, Korea, June 23-25, 2004.