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Yuanan (Ron) Lu
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Yuanan
(Ron) Lu, PhD
Professor, Environmental Health
1960 East West Road, Biomed D104K
Honolulu, HI 96822
email: ylu@pbrc.hawaii.edu
phone: (808) 956-2702
fax: (808) 956-5818 |
Academic Degrees
PhD (Microbiology), University of Hawai‘i at Mānoa
MS (Microbiology), Oregon State University
BS (Marine Biology), Huazhong Agricultural University
Awards/Honors
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Faculty Travel Awards, University Research Council,
University of Hawai‘i, 2006 & 2007 |
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Award from the National Science Academy
Foundation, China, 2003 |
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Traveling Exhibition Award, Microscopy Society of America,
1998 |
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Award, 2nd Prize in Biological Science, Microscopy Society
of America, 1998 |
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Third Place Award, Diatome U.S., Microscopy Society
of America, 1998 |
Research Interests (past and current)
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Novel gene therapy for HIV-1 infection |
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Development of novel gene transfer approaches for neuroAIDS |
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Modeling monocyte and macrophage based gene therapy
for neuroAIDS |
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New methods for environmental monitoring - pathogens
and toxic chemicals |
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Isolation of antiviral "drugs" from marine
microorganisms |
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Development of transgenic shrimp strains with viral
resistance |
Current Research Project and Funds
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Development of Gene Transfer Approaches
for NeuroAIDS (NINDS-NIH) |
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Establishment of Lentiviral Vector Mediated Transduction
and Expression of a Potential Neuro-protective Factor
in Mouse Monocytes and Macrophages (HCF) |
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Isolation and Identification of Anti-Viral Compounds
from Marine Microorganisms (COHH-NIH/NSF) |
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Establishment of a Newly Isolated Crustacean Promoter
Gene from Hawaii White Shrimp for Its Potential Application
in Transgenic Biotechnology (UH-RTRF) |
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Establishment and Characterization of Cell Lines from
Pacific Threadfin (Moi) for Use in Early Detection
and Control of Pathogenic viruses (CTSA) |
Dr. Yuanan Lu's research interests focus on
employing cutting-edge molecular biology and virology techniques
for the development of novel preventive and therapeutic strategies
to combat pathogenic viruses of human and marine species.
Several ongoing research projects include testing the potential
use of blood-derived monocytes/macrophages as a novel gene
delivery system for the central nervous system in vitro and
in vivo and testing/establishing different viral vector systems
in effective gene transfer applications. Current research
activities in Dr. Lu's laboratory also include the development
of fish cell lines for Hawai‘i Aquaculture Disease Management,
the employment of in vitro cell cultures as sensitive biological
indicators for enhanced monitoring of environmental pollution,
and the development of new methods to facilitate early detection,
effective prevention and control of environmental problems
including pathogenic viruses of marine animals and humans.
Courses Taught
PH 681 Environmental Determinants of Health
PH 696 Continuing Education in Public Health
PH 699 Directed Reading/Research
PH 781 Environmental Health Laboratory Methods
PH 797 Special Topics in Environmental Health
Selected Publications
Tan, F., Y. Lu, R. Tang, Y. Liu, W. Wang,
and M. Wang. 2008. Two new fish cell lines established from
fins and muscle of Chinese sucker, Myxocyprinus asiaticus.
Aquaculture (submitted).
Cao, S.B., Y.B. Yang, L.F. Sniderhan, S. Maggirwar,
H.Y. Dou, H.E. Gendeman, S. Dewhurst, and Y. Lu.
2008. Lentiviral vector-mediated expression of sTNFR-Fc in
stably transduced human macrophage and neuronal cells: implications
for NeuroAIDS therapeutic. J.Neurosc. Res (submitted).
Tan, F., M. Wang, F.X. Yang, and Y.
Lu. 2008. Establishment of a new fish cell line (RMF)
from rare minnow, Gobiocyris rarus, as versatile tool in ecotoxicology
assessment of cytotoxicity of heavy metals. Acta Hydrobioligica
Sinica (submitted).
Cox, C. S.B. Cao, and Y. Lu.
2008. Detection of murine norovirus-1 using more sensitive
murine microglial cells and reverse transcription-PCR). Applied
and Environmental Microbiology. (submitted).
Soderlund, M., C.X. Wu, and Y. Lu.
Molecular cloning and functional characterization of a newly
isolated putative ?-actin promoter from Hawaii white shrimp,
Litopenaeus vannanmei. Marine Biotechnology. (submitted).
Tan, F.X., M. Wang, W.M. Wang, A.A. Aguirre,
B. Wilcox, and Y. Lu. 2008. In vitro cytotoxicity
of four heavy metals to ten reptile cell lines derived from
green sea turtle (Chelonia mydas). Toxicology in Vitro. (submitted).
Asahina, A.Y, Y. Lu, C.X.
Wu, and P.C. Loh. 2008. Potential biosentinels of human waste
in marine coastal waters: Bioaccumulation of human caliciviruses
and enteroviruses from sewage polluted waters by indigenous
mollusks. J. Virol. Methods (submitted).
Wu, C.X. and Y. Lu. 2008.
Production of high-titer retroviral vector for effective transduction
of human and mouse cells of hematopoietic and lymphocytic
lineages. Virol. Journal. (submitted)
Lu, Y. 2008. Green fluorescent
protein (GFP) – lentiviral vectors: targeting neuroAIDS.
In: Hicks B.W. (editor), Methods in Molecular Biology: Viral
Applications of the GFP (in press).
Lu, Y. and L. Sniderhan. 2008.
Viral vector-mediated gene transfer. In: Schwab M. (editor),
Encyclopedia of Cancer. (in press)
Yang, Y.B., C.X. Wu, J.G. Wu, V.R. Nerurkar,
R. Yanagihara, and Y. Lu. 2008. Inhibition
of West Nile virus replication by retrovirus-delivered small
interfering RNA in human neuroblastoma. J. Med. Virol. 80:930-936.
Yang, F.X., A.A. Aguirre, S.W. Jin, B. Wilcox,
L. Rougée, Y. Xu, and Y. Lu. 2008.
Polybrominated diphenyl ethers in tilapia (Oreochromis mossambicus)
from O’ahu, Hawai`i. J. Environ. Monitoring 10:432-434.
Sniderhan, L.F, A. Stout, Y. Lu,
M.V. Chao, and S.B. Maggirwar. 2008. Role of Ankyrin-rich
Membrane Spanning Protein in Neurotrophin-mediated Activation
of Nuclear Factor-?B Signaling. Molecular and Cellular Neurosci.
38:404-416.
Yang, F.X., B. Wilcox, S.W. Jin, A. A. Aguirre,
L. Rougée, Y. Xu, and Y. Lu. 2008.
Concentration and toxic equivalency profile of polychlorinated
biphenyls in Tilapia from Hawaiian waters. Chemosphere. 73:133-137.
Wu, C.X., V.R. Nerurkar, R. Yanagihara, and
Y. Lu. 2008. Effective modifications for
improved homologous recombination and high efficiency generation
of recombinant adenovirus-based vectors. J. Virological Methods.
153:120-128.
Wu, C.X. and Y. Lu. 2007.
Addition of high molecular weight dextran in calcium phosphate-mediated
transfection significantly improves gene transfer efficiency.
Cellular and Molecular Biology. 53(4):67-74.
Sun, P.S., M. Soderlund, N.C. Venzon Jr., D.
Ye, and Y. Lu. 2007. Isolation and characterization
of two actins of the Pacific white shrimp, Litopenaeus vannamei.
Marine Biology. 151:2145-2151.
Rougee, L., G.K. Ostrander, R.H. Richmond,
and Y. Lu. 2007. Establishment, characterization,
and viral susceptibility of two cell lines derived from goldfish
muscle and swim bladder Carassius auratus. Dis. Aquat. Org.
77:127-135.
Cao, S.B., Y.B. Yang, S. Maggirwar, S. Dewhurst,
and Y. Lu. 2007. Effective expression of
sTNFR-Fc in stably transduced mononuclear phagocytes and neuronal
cells: implications for neuroAIDS therapeutics. J. Neurovirology.
13(S1):71.
Sniderban, L.F., S.H. Ramirez, A. Litzburg,
Y. Lu, M.V. Chao, and S.B. Maggirwar. 2007.
Unique role of ARMS in neurotrophin-mediated activation of
NF-kB and neuronal protection against HIV-1 encoded gp120.
J. Neurovirology. 13(S1):125.
Tan, F, M. Wang, W. Wang, and Y. Lu.
2007. Cytotoxicity sensitivity of six fish cell lines to four
common heavy metals. Toxicology in Vitro. 22:164-170.
Zeng, L.B., V. Planelles, Ziye Sui, S. Gartner,
S.B. Maggirwar, S. Dewhurst, L.B. Ye, V.R. Nerurkar, R. Yanagihara,
and Y. Lu. 2006. Human immunodeficiency virus
type 1 (HIV-1) based defective lentiviral vectors efficiently
transduce human monocyte-derived macrophages and suppress
replication of wild-type HIV-1. J. Gene Med. 8:18-28.
Zhao, Z.S. and Y. Lu. 2006.
Establishment and characterization of two cell lines from
bluefin trevally Caranx melampygus. Dis. Aquat. Org. 68:91-100.
Zeng, LB, S.M. Yang, C.X. Wu, V. Planelles,
S. Dewhurst, L.B. Ye, and Y. Lu. 2006. Effective
transduction of primary mouse blood- and bone marrow-derived
monocytes/macrophages by HIV-1-based defective lentiviral
vectors. J. Virol. Methods. 134:66-73.
Wu, J.M., S.M. Yang, H.Y. Luo, M. Nguyen, L.B.
Zeng, Y. Lu. 2006. Quantitative evaluation
of monocyte transmigration into the brain following chemical
opening of the blood-brain barrier in mice. Brain Res. 1098:79-85.
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