Shohet Lab - University of Hawaii

Recent Publications

Le Saux CJ, Miyasato SK, Hoffmann PR, Douet V, Shohet RV, Broide DH, Tam EK. Down-regulation of caveolin-1, an inhibitor of TGF-ß signaling, in acute allergen-induced airway remodeling. J Biol Chem, in press, 2008.

Shohet RV and Garcia JA. Keeping the engine primed: HIF factors as key regulators of cardiac metabolism and angiogenesis during ischemia. J Mol Medicine, in press, 2008.

Chun SG, Harada GL, Matsui DK, Nywening TM, Shohet RV. Broken heart syndrome a critical review of transient left ventricular apical ballooning, Hawaii Medical Journal, 66:265-67, 2007.

Lund AK, Knuckles TL, McDonald JD, Shohet RV, Seagrave J-C, Campen MJ. Gasoline exhaust emissions induce vascular remodeling pathways involved in atherosclerosis. Toxicol Sci. 95:485-94, 2007.

Flood EM, Kumar RS, Shah R, Amos Q, Wren JD, Shohet RV, Garner HR. (2006) Melatonin administration does not affect isoproterenol-induced LVH. IEEE Eng Med Biol Mag. 25(3):84-87.
Chen S, Ding JH, Bekeredjian R, Yang BZ, Shohet RV, Johnston SA, Hohmeier HE, Newgard CB, Grayburn PA. (2006) Efficient gene delivery to pancreatic islets with ultrasonic microbubble destruction technology. Proc Natl Acad Sci USA 103(22):8469-8474.
Shohet RV, Grayburn PA. (2006) Potential bioeffects of ultrasonic destruction of microbubble contrast agents. J Am Coll Cardiol. 47(7):1469-1470.
Mineo C, Gormley AK, Yuhanna IS, Osborne-Lawrence S, Gibson LL, Hahner L, Shohet RV, Black S, Salmon JE, Samols D, Karp DR, Thomas GD, Shaul PW. (2005) FcgammaRIIB mediates C-reactive protein inhibition of endothelial NO synthase. Circ Res. 97(11): 1124-1131.
Yi X, Bekeredjian R, Defilippis NJ, Siddiquee Z, Fernandez E, Shohet RV. (2005) Transcriptional analysis of doxorubicin-induced cardiotoxicity. Am J Physiol Heart Circ Physiol. 290(3): H1098-1102.
Korpanty G, Grayburn PA, Shohet RV, Brekken RA. (2005) Targeting vascular endothelium with avidin microbubbles. Ultrasound Med Biol. 31(9): 1279-1283.
Bekeredjian R, Chen S, Grayburn PA, Shohet RV. (2005) Augmentation of cardiac protein delivery using ultrasound targeted microbubble destruction. Ultrasound Med Biol. 31(5): 687-691.
Korpanty G, Chen S, Shohet RV, Ding J, Yang B, Frenkel PA, Grayburn PA. (2005) Targeting of VEGF-mediated angiogenesis to rat myocardium using ultrasonic destruction of microbubbles. Gene Ther. 12(17): 1305-1312.
Maresh JG, Xu H, Jiang N, Gairola CG, Shohet RV. (2005) Tobacco smoke dysregulates endothelial vasoregulatory transcripts in vivo. Physiol Genomics. 21(3): 308-313.
Bekeredjian R, Grayburn PA, Shohet RV. (2005) Use of ultrasound contrast agents for gene or drug delivery in cardiovascular medicine. J Am Coll Cardiol. 45(3): 329-335.

Significant Publications

Zhao XS, Pan W, Bekeredjian R, Shohet RV. (2006) Endogenous Endothelin-1 Is Required for Cardiomyocyte Survival In Vivo. Circulation. 114(8):830-837.
Shohet RV, Kisanuki YY, Zhao XS, Siddiquee Z, Franco F, Yanagisawa M. (2004) Mice with cardiomyocyte-specific disruption of the endothelin-1 gene are resistant to hyperthyroid cardiac hypertrophy. Proc Natl Acad Sci USA. 101(7): 2088-2093.
Zhao S-X, Gallardo TD, Lin L, Schageman JJ, Shohet RV, (2002) Transcriptional mapping and genomic analysis of the cardiac atria and ventricles. Physiological Genomics. 12:53-60.
Shohet RV, Chen S, Zhou Y-T, Wang Z, Meidell RS, Unger R, Grayburn PA, (2000) Ultrasonic disruption of albumin microbubbles directs gene delivery to the myocardium. Circulation. 101:2554-2556.