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PRODID:-//University of Hawaii//UH Events Calendar//EN
VERSION:2.0
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TZID:Pacific/Honolulu
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CLASS:PUBLIC
CREATED:20261016T081922Z
DESCRIPTION:"Antiviral Activity of Favipiravir Against Henipaviruses" by Alexander Freiberg, Ph.D., Assistant Professor, Department of Pathology, Director, Robert E. Shope BSL-4 Laboratory, University of Texas Medical Branch, Galveston, Texas\n\n\n\n\n\n\nNipah virus (NiV) and Hendra virus are recently emerged bat-borne paramyxoviruses of the Henipavirus genus which cause severe acute respiratory and encephalitic diseases in humans. The case-fatality rate ranges from 40-90%, depending on the size of the outbreak. Currently, no vaccines or therapeutics are approved for use in humans. Favipiravir (T-705) is an RNA-dependent RNA polymerase inhibitor that has been approved for use against influenza virus in Japan and has displayed broad-spectrum efficacy against multiple RNA viruses (including filo-, arena- and bunyaviruses). Here, we demonstrate the in vitro activity of T-705 against henipaviruses and in vivo efficacy in a small animal model for NiV. \n
DTEND;TZID=Pacific/Honolulu:20160520T230000Z
DTSTAMP:20261016T081922Z
DTSTART;TZID=Pacific/Honolulu:20160520T220000Z
LAST-MODIFIED:20261016T081922Z
LOCATION:John A. Burns School of Medicine, Kaka’ako Campus, 651 Ilalo Street, MEB Auditorium (Room 315)
PRIORITY:5
SEQUENCE:0
SUMMARY;LANGUAGE=en-us:COBRE/Tropical Medicine Seminar
TRANSP:OPAQUE
UID:179217476228934web-support-l@lists.hawaii.edu
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