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TZID:Pacific/Honolulu
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CLASS:PUBLIC
CREATED:20260411T015201Z
DESCRIPTION:TRMD 690 Wednesday, January 20, 2021 via Zoom @ 12:00 PM - 1:00 PM *****Zoom Link: https://zoom.us/j/94805199979 Call in: (669) 900-6833 Zoom ID: 948 0519 9979 Passcode: 539158 *****"SARS-CoV-2 Biology and Countermeasure Development"I will present two COVID-19 studies. (i) We have developed a reverse genetic system and reporter virus for SARS-CoV-2. These genetic tools have been used for serodiagnosis, vaccine, and antiviral development. Using a reporter SARS-CoV-2-based neutralization assay, we have supported the preclinical development and phase 1/2 clinical trials of Pfizer/BioNTech’s vaccine, leading to the first COVID-19 vaccine with 95% efficacy in humans; (ii) We recently showed that spike D164G substitution, which became dominant over the course of pandemic, significantly enhances viral replication in primary human airway cultures. When infecting hamsters, the D164G mutation increased viral fitness in the upper respiratory tract, but not in the lungs, supporting the increased potential for viral transmission.******Pei-Yong Shi, Ph.D.,\nJohn Sealy Distinguished Chair in Innovations in Molecular Biology\nVice Chair for Innovation and Commercialization,\nDepartment of Biochemistry & Molecular Biology,\nUniversity of Texas Medical Branch at Galveston\n
DTEND;TZID=Pacific/Honolulu:20210120T230000Z
DTSTAMP:20260411T015201Z
DTSTART;TZID=Pacific/Honolulu:20210120T220000Z
LAST-MODIFIED:20260411T015201Z
LOCATION:via Zoom
PRIORITY:5
SEQUENCE:0
SUMMARY;LANGUAGE=en-us:JABSOM Tropical Medicine Seminar
TRANSP:OPAQUE
UID:177590832138232web-support-l@lists.hawaii.edu
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