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PRODID:-//University of Hawaii//UH Events Calendar//EN
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TZID:Pacific/Honolulu
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CLASS:PUBLIC
CREATED:20260418T222213Z
DESCRIPTION:Skin cancer is the most prevalent cancer in the United States and is strongly associated with ultraviolet (UV) radiation that damages DNA and generated many mutations. It is critical to avoid excessive sunlight in order to prevent skin cancer. Also, chemoprevention id of great interest. Human epidemiological studies and our mouse studies showed that caffeine prevents UV-induced skin carcinogenesis. We found that the most relevant target of caffeine for skin cancer prevention is the ATR kinase, which senses UV-induced DNA Lesions and stops the cell cycle. Genetic inhibition of ATR augmented UV-induced apoptosis and suppressed UV-induced skin cancer development.
DTEND;TZID=Pacific/Honolulu:20250521T230000Z
DTSTAMP:20260418T222213Z
DTSTART;TZID=Pacific/Honolulu:20250521T220000Z
LAST-MODIFIED:20260418T222213Z
LOCATION:UH Cancer Center, Sullivan Conference Center
PRIORITY:5
SEQUENCE:0
SUMMARY;LANGUAGE=en-us:Caffeine & Epigenetics:Novel Approaches to Prevent and Treat UV- Induced Cance
TRANSP:OPAQUE
UID:177658693344170web-support-l@lists.hawaii.edu
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