Skip to content
Reading time: 4 minutes
person measuring out samples
PhD student Brennan Yamamoto performs a type 2 diabetes test on a sample from a study participant.

A potential link between intestinal bacteria and the disproportionately higher rates of certain chronic disease and mental health risks among Native Hawaiians and other Pacific Islanders (NHPIs) has been discovered by an interdisciplinary team of researchers from the University of Hawaiʻi at Mānoa. The new findings were published in a series of articles in Frontiers, the world’s third most-cited research publisher.

person drawing blood from another person
Post-baccalaureate phlebotomist Rosa Lee obtains a blood sample through venipuncture.

Researchers from UH Mānoa’s John A. Burns School of Medicine (JABSOM) and the University of Hawaiʻi Economic Research Organization (UHERO) in the College of Social Sciences have identified key differences in the numbers and types of intestinal bacteria strains in NHPIs that track with age, type 2 diabetes status, body mass index and self-esteem. Using these profiles, they identified specific features that may partially regulate the biological processes that impact mental health and metabolic conditions that appear to be related to inflammation, and may help explain the higher incidences of depression and diabetes among NHPIs. Examples of these findings include:

  • A novel interaction between self-esteem and abundance of Veillonellaceae bacteria, where increased levels of this bacteria in the gut corresponded to a significant increase in self-esteem, with individuals with low self-esteem (a risk factor for depression) showing abnormally low levels of this bacteria.
  • Shared imbalance of Bacteroidetes between diabetes and obesity, where its abundance was observed to decrease with poor glycemic control and increase with obesity.
  • A significant and specific deficiency in the levels of butyrate-producing bacteria in the gut of pre- and diabetic participants, that corresponded to increased systemic inflammation.
  • A novel significant association between the levels of Cyanobacteria (which produces toxins and implicated in cancer risk in Hawaiʻi) and poor glycemic control, with overabundance of this bacteria in the gut of diabetic participants.
  • A significantly higher gut microbial diversity in obese and diabetic individuals of NHPI ancestry. This contrasts with the relationship observed between obesity and diabetes in other ethnic/race groups previously reported in other studies.
person smiling
Alika Maunakea

The new research is based on survey findings from a cohort of more than 500 Hawaiʻi residents statewide. The surveys were conducted by UH’s Hawaiʻi Social Epigenomics of Early Diabetes Cohort (HI-SEED) project and designed to identify novel biomarkers predictive of the development of diabetes in order to enable prevention and restore health equity in the islands.

The results indicate that biological findings from other ethnic/race groups may not necessarily be generalizable to the NHPI population and highlight the importance of increasing representation of NHPIs in social and biomedical research studies.

“Your gut microbiome is affected by what you eat and your environment, and for the first time, we have uncovered differences in Native Hawaiian and Pacific Islanders that contrast with findings from other populations. This may better explain higher rates of chronic health conditions such as diabetes among NHPIs that cannot be explained by social environmental factors alone,” said report co-author Alika Maunakea, associate professor at the Department of Anatomy, Biochemistry and Physiology at JABSOM.

person smiling
Ruben Juarez

According to the Hawaiʻi State Department of Health, NHPIs suffer disproportionately higher rates of and deaths from type 2 diabetes than any other major race/ethnic group in the state. In 2018, the age-adjusted diabetes death rate among NHPIs was more than 2.5 times higher than that of the general state population. Studies have also shown that NHPI have a higher prevalence of depressed moods, suicidal ideation and attempts and illicit drug use, but are three times less likely to receive mental health services and treatment compared to non-Hispanic white people. While existing research has described social determinants of mental health in this population, little is known about the biological mechanisms underlying the disproportionately higher rates of low self-esteem related to depression among NHPIs.

“Our findings have significant implications for personalized medicine and improved strategies to enable interventions aimed at preventing chronic disease outcomes, especially among NHPIs. In working with NHPI-led community-based organizations, we are already observing some promising results of such strategies,” added co-author Ruben Juarez, HMSA Endowed Professor in Health Economics in UHERO.

Preventing chronic diseases among NHPIs

One example is a partnership with MAʻO Organic Farms, which is located in Waiʻanae with a dense NHPI population. The MAʻO Organic Farms’ Youth Leadership Training (YLT) program connects ʻāina (that which feeds) and ʻōpio (youth) to create a local food system that incorporates education, healthy lifestyle and socioeconomic development. YLT interns experience improvements in attaining higher-level education, nutrition, physical activity, access to health care and cultural literacy, potentially reducing the risk of chronic disease conditions prevalent in that community. The pilot program has shown to reduce the risk for diabetes among oncoming YLT interns after a year in the program.

Sponsored by the National Institutes of Health, HI-SEED is led by Maunakea with the support of Juarez, and includes researchers from JABSOM, College of Social Sciences, UHERO and the UH Cancer Center.

Participate in the study

Recruitment of the HI-SEED cohort participants is ongoing and is open to qualified Hawaiʻi residents who are between the ages of 20 and 50. Selected participants are required to complete a comprehensive questionnaire, anthropometrics exam and contribute blood and stool samples. Learn more about the project and eligibility criteria.

Read the full research articles:

Back To Top